Vaccines have been providing humankind the ability to defend against viruses that can cause disease. However, current vaccines still have challenges to overcome such as a risk of side effect and low immunogenicity. In the present work, we developed a self-assembled vaccine (SAV) platform based on antigen conjugated with an amphiphilic block copolymer, mPEG-b-PLA-NHS. To improve immunity of subunit vaccine, SAV was designed to display repetitive antigens in nanoscale for eliciting efficient antigen delivery and immune cell activation via multivalent recognition. SAV exhibited enhanced cellular uptake by dendritic cells (DCs), facilitating an efficient initiation of the adaptive immune system. SAV showed high level of induction of IgG, IgG1, and IgG2 through in vivo analysis, implying efficient B cell activation and T cell mediated immune response. Furthermore, we confirmed that SAV comprising of hemagglutinin (HA) efficiently protected mice from death associated with infection of influenza virus. These findings suggest that the self-assembled nano-system composed of antigen-polymer conjugate can be a potent vaccine platform with effectiveness and versatility.

Virus-mimetic vaccine based on self-assembled antigen-polymer eliciting effective immunity against Influenza virus

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.