This poster describes recent development of novel biodegradable and environmentally safe salicylic acid-based poly(anhydride-ester)s (SAPAEs) copolymers for controlled release of small molecule upon copolymer hydrolytic degradation. Previously, our group has showed that SAPAEs homopolymers are effective for controlling inflammation, promoting bone growth, and preventing biofilm formation due to the release of salicylic acid as the polymers degrade. Not only can these polymers be manipulated into different geometries (e.g powders, fibers, microspheres, disks, films, cardiac stents), the degradation and salicylic acid-release rate of SAPAEs can also be modulated by changing the chemical compositions of the polymers and linker molecules. The tunability of these polymers and their biocompatibility are thus of great potential for different uses including pharmaceutical, food, agriculture. Therefore, advances to create new SAPAEs polymers with various release rates and tunable properties will open a wide range of opportunities for these applications. Here, we describe the preparation of a series of novel SAPAE-based copolymers microspheres as well as evaluate their degradation and encapsulation characteristics for small molecule release. Our results demonstrate that these SAPAEs copolymers act as an effective protecting capsule for the encapsulated substrate of interest and readily degrade to release it with additional therapeutic benefits of salicylic acid at various rates.

Evaluating poly(anhydride-ester)s’ hydrolytic degradation & encapsulation characteristics for small molecule release

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ACS Fall 2022

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