Azetidines and azetines are 4-membered nitrogen containing heterocycles that are found in natural products and have immense potential in the design of pharmaceuticals. Difficulties and limitations in the synthesis of azetidines and azetines has, in part, limited the investigation of the applications of these desirable motifs. Methods have been previously reported that use visible-light-facilitated methods to access azetidines and 1- and 2-azetines via a [2+2]-cycloaddition strategy from alkene or alkyne containing precursors. Herein, we report a novel method to access 1-azetines via a tandem catalytic approach.

Synthesis of 1-azetines via transition-metal catalysis

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.