Microbes are essential for all life on earth; they cycle elements in the environment and are essential to maintain human health. Thus, disease and dysbiosis can occur when these microbes are not in homeostasis. Living biotherapeutics are important to prevent and combat these issues. However, the stable formulation, production, and storage of many gram-negative strains of interest remain a challenge. We have developed a self-assembling cellular coating to improve the viability and stability of Bacteroides thetaiotaomicron, which could be used as a next-generation biotherapeutic. We show protection from processing and oxygen exposure following freeze-drying, even without cryoprotectants. This material will enable significantly more microbes to be stably produced for human health and agriculture applications.

Self-assembling materials to protect microbes from processing stresses

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.