Polymeric materials for drug delivery are typically centered around targeted and controlled release in cancer cell conditions, particularly the acidic pH. Thus the pH triggered degradation of polymers has been studied in these mild conditions for their potential as drug carriers. Poly(silyl ether)s (PSEs) are therefore appealing because of their ability to undergo hydrolytic degradation due to the labile Si-O-C linkages. In this study we have synthesized a series of linear PSEs and nanoparticles based on these PSEs. Degradation and cytotoxicity studies are performed on the polymers while encapsulation, release, and cytotoxicity studies are performed on the nanoparticles.

Poly (silyl ether)-based polymeric nanoparticles as potential nanocarriers for drug delivery applications

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