Dental caries is a multifactorial disease that leads to the localized destruction of susceptible dental tissues. In a recent Lancet study of global burden of 328 major diseases dental caries was identified as the most prevalent disease worldwide. US National Health and Nutrition Examination Survey reports the dental caries incidence rate of 42% in young children and more than 92% in adults. In spite of its general classification as a ‘life-style-related disease’, dental caries can result in tooth loss, infection, and in some cases, even death by sepsis. Due to the severity of its prevalence and the magnitude of the treatment cost, dental caries is considered as a major public health concern. Although several oral bacteria have been associated with different forms of dental caries, Streptococcus mutans has been implicated as the major etiological agent in the initiation and development of dental caries. The formation of tenacious biofilms is the hallmark of S. mutans induced pathogenesis of dental caries. We have identified novel hydroxyaurone molecules as specific inhibitors of S. mutans biofilm that do not affect the growth of oral commensal bacterial species. These compounds are inhibitors of S. mutans glucosyl transferases. The design, synthesis and biological evaluations of these hydroxyaurones will be presented in the poster.

Biofilm inhibiting hydroxyaurones with in vivo anticariogenic activity against Streptococcus mutans

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.