In the quest to efficiently improve the analytical performance of photoelectrochemical (PEC) biosensor, exploring ideal photoelectrode with superb photoelectric properties has been actively pursuing among the field. SnO2, as a n-type semiconductor with high electron mobility and photostability, can be considered as promising candidate. In our study, paper-based one-dimensional domed SnO2 nanotube array has been developed through a sample but effective template-consumption strategy, and its growth mechanism is also proposed based on systematic experiments. In this synthetic process, the typical amphoteric oxide of ZnO nanorods are firstly grown on paper substrate, serving as the sacrifice template which can be dissolved by the alkaline environment produced during the formation of SnO2. By means of controlling the experiment conditions, the ZnO template can be etched off completely, leading to the formation of paper-based hollow domed SnO2 nanotube array. In addition, self-doping strategy is also employed to extend the light absorption range to visible region and facilitate the charge separation via tailoring the electronic structure of SnO2 nanotubes, thereby enabling efficient activation of paper-based SnO2 nanotube array under visible light radiation for generating prominent photocurrent signal. Ultimately, an innovative paper-based SnO2-x nanotube array with desirable PEC performance is constructed and utilized as photoelectrode for ultrasensitive PEC detection of model analyte alpha fetoprotein (AFP). Profiting from the significant PEC signal produced by the as-prepared photoelectrode, the developed lab-on-paper PEC biosensor exhibit a low detection limit of 3.84 pg/mL (S/N = 3). This work offers an advisable strategy for the exploitation of novel photoelectrode for paper-based PEC biosensor.

Lab-on-paper photoelectrochemical bioassay enabled by paper-based visible light responsive domed SnO2-x nanotubes

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.