The ability to continuously monitor the concentration of specific molecules in interstitial fluid (ISF), a body compartment with a chemical composition that can rapidly equilibrate with that of systemic blood, could enable the unprecedented assessment of molecular concentrations that reflect full-body physiology in health and disease. In the past, continuous monitoring in ISF was enabled by microneedle sensor arrays. Yet, benchmark microneedle sensors can only detect molecules that undergo redox reactions. This presentation, in contrast, will discuss the use of microneedle-supported electrochemical, aptamer-based (E-AB) sensors, a platform that achieves molecular recognition based on affinity interactions, vastly expanding the scope of molecules that can be sensed via wearable microneedle monitors.

Microneedle aptamer-based sensors for continuous, real-time molecular monitoring

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.