Besides being the primary energy source, carbohydrates and other sugar moieties are also necessary for synthesizing other biomolecules, which broaden their importance in nearly all biological processes. Consequently, the processing of carbohydrates is biologically essential and, therefore, is relevant to many diseases like diabetes, cancer, and hepatitis<br/>Consequently, the processing of carbohydrates is biologically essential and, therefore, is relevant to many diseases like diabetes, cancer, and hepatitis. Carbohydrate processing enzymes (i.e., glycosidases) only recognize sugars of specific stereochemistry. Sugar analogs known as iminosugars can inhibit carbohydrate handling enzymes and as a result are being investigated as potential therapeutic candidates for diseases associated with the processing of carbohydrates. One important class of iminosugars is polyhydroxylated indolizidine. This research aims to synthesize two (17 and 18) of the 32 possible stereoisomers of a tetrahydroxylated indolizidine.

Approach to polyhydroxylated indolizidine synthesis

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