We have demonstrated a visible-light-mediated metal-free organic-dye-catalyzed dehydrogenative N-insertion leading to highly substituted imidazoles and privileged dihydro isoquinoline-based imidazole derivatives via C(sp3 )−H and C- (sp2 )−H bond functionalization. A sustainable, convenient, metal-free azidation/C−H aminative cyclization approach in the absence of stoichiometric oxidants is presented. This protocol involves a rare photoinduced iminyl radical as a key intermediate for the “N” insertion. Furthermore, this protocol furnishes interesting −CF3-substituted imidazoles, which would be of great significance as therapeutic agents due to the enhanced.

Photocatalytic visible-light-induced nitrogen insertion via dual C(sp3 )−H and C(sp2 )−H bond functionalization: Access to privileged imidazole-based scaffolds

Where thousands of chemistry professionals meet to share ideas and advance scientific and technical knowledge. Spring 2023 abstracts, posters, and presentations will launch at the end of March.

ACS Spring 2023

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.