The antibacterial activity of novel, biocompatible polyethylene glycol functionalized CuO-ZnO nanomaterials is well presented in this study. CuO-ZnO nanomaterials were synthesized in the presence of 2 w/v % polyethylene glycol 20 000 (PEG) by co-precipitation method in which Cu was incorporated in weight ratios of (Cu:Zn) 1:1, 1:2 and 2:1, and was hydrothermally coupled at 180 °C for 15 hours. Synthesized nanomaterials were characterized by X-ray diffractometry (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Raman spectroscopy and X-ray photoelectron spectroscopy (XPS) and Brunauer, Emmett and Teller surface area analyzer. All the synthesized composites possess CuO-ZnO crystallography as suggested by XRD and confirmed by Raman spectroscopy while the surface was composed of Cu2+and Zn2+ as revealed by XPS. ZnO nanomaterials show flower-like morphology in both SEM and TEM images while the CuO-ZnO nanomaterials exhibited a mixture of flower-like structures and macrorods of about 150 nm width and 3 µm in length. The appearance and the size of the flower-like structures varied in different composites and the number of macrorods increased with the increasing amount of Cu incorporated. The antibacterial activity of the synthesized nanomaterials was determined on Escherichia Coli and Staphylococcus aureus using the agar well diffusion method. ZnO nanomaterials were more effective in inhibiting the growth of both bacterial species than the synthesized nanocomposites being more effective in inhibiting the growth of Staphylococcus aureus than of E. Coli as shown by the diameter of the inhibition zone for Staphylococcus aureus (25.50±0.70 mm) being greater than that for E. Coli (14.33±0.58 mm). The antibacterial activity against E.Coli by the synthesized nanomaterials varied as ZnO &gt; Cu:Zn 1:1 &gt; 2:1 &gt; 1:2 and that for Staphylococcus aureus varied as ZnO&gt; Cu:Zn 1:2 &gt; 2:1 &gt; 1:1. Morphology, size and composition of the nanomaterials collectively have contributed to the antibacterial activity.

Antibacterial activity of biocompatible PEG functionalized CuO-ZnO nanomaterials

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