The synthesis and structure-activity-relationship for a series of insecticidal pyrazole carboxamide compounds will be discussed. The progress from a Hit to a Lead was enabled by a systematic SAR study that led to improved potency and spectrum on key target pests. Scaffold hop approaches guided by QSAR, 3D structure overlays and fragment based approaches to overcome the activity plateau will also be discussed.

Pyrazole-carboxamides as chewing insecticides: Chemistry, structure-activity-relationship and scaffold hop approaches

Where thousands of chemistry professionals meet to share ideas and advance scientific and technical knowledge. Spring 2023 abstracts, posters, and presentations will launch at the end of March.

ACS Spring 2023

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.