Photoredox catalysis is a viable method of functionalization that makes use of electron-transfer to access new reactive pathways in the synthesis of N-heteroarenes. The relevance of biologically active N-heteroaromatic compounds in drug discovery make a crucial case for developing more efficient functionalization methods that utilize the most basic organic feedstocks.  Our laboratory focuses on the design and synthesis of photocatalysts that can induce a one-electron transfer under photochemical reaction conditions. High-throughput screening of these reactions is utilized to assess their performances and determine what alterations need to be made to achieve optimal yield and sustainability. Herein, we will detail our investigations of using these photocatalysts to perform a C-H activation of the N-heteroarenes we have discovered.

C-H activation of N-heteroaromatic compounds by photocatalysis

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