Glycosphingolipids (GSLs) are one type of structurally complex glycolipids found in the cell membranes of organisms including bacteria and animals. GSLs are known to play significant biological roles in membrane structure, cell–cell recognition, host–pathogen interactions as well as modulation of membrane protein function. Access to pure and structurally well-defined glycosphingolipids has been achieved by chemical and chemo-enzymatic synthesis. In this presentation, we will describe an approach for the synthesis of glycosphingolipids via stereoselective anomeric O-alkylation of sugar lactols with suitable electrophiles.

Synthesis of glycosphigolipids via stereoselective anomeric O–alkylation

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