Bisphosphonates are a biologically important class of compounds that aid in the prevention of bone loss and are primarily used in treatment of diseases such as osteoporosis, Paget disease, and cancer that is metastatic to bone. Lesquerella oil, from the plant Physaria fendleri, contains a high amount of lesquerolic acid, a hydroxy fatty acid (HFA) that is structurally similar to ricinoleic acid, the major component of castor oil. The similarity of lesquerella oil to castor oil is important because the production of castor oil has many health and safety concerns due to the presence of ricin (a highly poisonous substance) in the seeds. The purpose of this project is to synthesize bisphosphonates derived from lesquerella oil to understand the potential use and application of this oil. Progress towards the synthesis of a family of bisphosphonates derived from lesquerolic acid will be presented.

Synthesis of lesquerella oil derived bisphosphonates

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