To address the excess chemotherapeutic drugs like doxorubicin, filtration devices are introduced to be deployed in the vein draining the organ where a closed system is formed so the drug would be prevented from leaving the organ causing systemic toxicity. By maximizing surface area and interaction time for drug binding, drug capture performance can be improved. Here, we introduce the use of dual phase microlattice design for the cross-section of these filtration devices to improved drug capture. With the use of additive manufacturing(AM), fabrication of materials with arbitrarily complex geometries in a single processing step is convenient. Here, we refer to previous studies and adapt their effective coating technique to ensure that the cross-section of the device has affinity to the drug and that we only investigate improved drug capture via microlattice design. A modelling approach is developed to resolve the flow through the cross-section and subsequently characterize the performance of the device. This study aims to contribute to body of knowledge to further minimize the side effects of chemotherapy.

Additive manufacturing of polymeric dual phase microlattices as cross-section of chemotherapy drugs absorbers for improved capture

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