Subcellular compartmentalization is a key feature of eukaryotic cells. Selectively targeting subcellular organelles, though holding many exciting opportunities for biomedicine, remains underdeveloped. Enzyme-instructed self-assembly (EISA), an approach that integrate enzymatic reactions and self-assembly, allows dynamic conversions from single molecules into larger supramolecular nanostructures for targeting subcellular organelles. In this talk, we discuss the use of EISA to generate artificial intracellular nanostructures for targeting mitochondria, endoplasmic reticulum, Golgi apparatus, lysosomes, and nucleus. Particularly, we will show the use of EISA to generate small molecule assemblies, as in-situ nanomedicine, for developing therapeutics to counter drug resistance and immunosuppression in cancer therapy.

Intracellular supramolecular assemblies/colloids

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ACS Spring 2023

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