Monolithic chromatography uses a monolithic column consisting of a singular porous material, typically made of silica or an organic polymer. This study focuses on preparation of organo-silica hybrid monoliths utilizing 3-methacryloxypropyltrimethoxysilane as a starting monomer. In our previous work we have shown how addition of ethylene dimethacrylate as the cross-linker enhanced column stability and resulted in prolonged retention, better selectivity, and resolution of alkylbenzenes. Here the attention is on implementing other cross-linking monomers from methacrylates to multithiols. At first, optimization of polymerization mixture composition is performed in vials and is followed by FTIR analysis to assess incorporation of various functionalities into the structure. Subsequently, capillary liquid chromatography is used to evaluate the suitability of monolithic column (100 µm ID) as separation media of small analytes in reversed-phase mode.

Effect of cross-linkers on formation of organo-silica hybrid monolithic columns for applications in capillary liquid chromatography

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