Peptidoglycan (PG) is a dynamic and major constituent of bacterial cell walls in both Gram-positive and Gram-negative bacteria. Recent studies have suggested a relationship between irregular PGs in the bacterial genus <i>Borrelia </i>and the development and persistence of Lyme arthritis. Since antibodies often bind to receptors on peptidoglycan cell walls, artificially synthesized PGs could serve as diagnostic tools for Lyme disease. However, the chemical synthesis of structurally well-define peptidoglycan fragments has been complicated by long syntheses and challenging stereo- and regioselectivity issues. Herein we report the first efforts to develop a robust, reproducible, and easy scalable automated flow processes for the synthesis of modular building blocks for the production of bacterial PG fragment libraries.

Advances towards complex polysaccharides and peptidoglycans using automated flow chemistry

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