The production of cutting-edge materials, development of novel medications, drug delivery, technological advancements, and biosynthesis all depend on molecular building blocks. In this study, the design, synthesis, and characterization of paired coiled-coil peptidic molecular building blocks are shown. Several unique oligopeptides were designed and successfully prepared incorporating two modified ornithine residues. Linkers were attached to these residues via solid-phase copper-catalyzed azide-alkyne cycloaddition (SP-CuAAC) click reactions and selected peptide pairs were then crosslinked. The design, synthesis, and use of these oligopeptides in the controlled self-assembly of coiled coils will be described.

Synthesis and the controlled self-assembly of coiled-coil oligopeptides

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