Neurons are highly polarized cells forming an intricate network of dendrites and axons. They are shaped by the dynamic reorganization of cytoskeleton components and cellular organelles. Axon growth is controlled by the external stimuli. Axon branching allows the formation of new paths and increases circuit complexity. Finally, neuronal maintenance, the process of regeneration and degeneration are critical points for the remodeling of the circuit. However, our understanding of the neuronal morphogenesis is sparse at a molecular level due to the lack of direct in-depth observations. Using in situ cellular cryo-electron tomography on primary neurons, we aim to understand the molecular actions of the remodeling of organelles and cytoskeleton structures during the critical events of neuronal morphogenesis. In this talk, I will discuss about our recent molecular findings of neuronal regeneration.

Molecular neurobiology by cryo-ET

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