Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) was used to analyze pure quinine. SALDI-MS reduced the fragmentation and increased ion formation with the removal of a matrix interference. To increase ion formation and energy desorption, transition metal oxide (TMO) nanoparticles were used as surfaces for quinine. TMO nanoparticles were used because they offer a large surface area-to-volume ratio for the analyte to receive enough energy to ionize and produce a higher signal with low background interference. In previous studies, iron (II,III) oxide (Fe3O4) and cobalt (II,III) oxide (Co3O4) were successfully used to study small biomolecules. In this study, pure quinine was analyzed using small iron (II,III) oxide, large iron (II,III) oxide, small cobalt (II,III) oxide and large cobalt (II,III) oxide nanoparticles as SALDI-MS surfaces. The data was analyzed by comparing the average peak intensities and signal-to-noise (S/N) for each nanoparticle, and were run multiple times to ensure reproducibility.

Analysis of quinine using surface-assisted laser desorption/ionization mass spectrometry

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