Real-time detection of electroactive neurochemicals in the brain has been made possible by the use of carbon fiber microelectrodes in combination with fast-scan cyclic voltammetry (FSCV). The surface heterogeneity of CFMEs makes it very challenging to consistently modify them chemically and structurally, despite their broader potential window, stability, and low limits of detection. To improve electrochemical detection graphene-based materials have been used in neurochemical detection. Graphene-based fibers are extremely conductive, flexible, lightweight, frequency independent, and have fouling resistance property boosts the sensitivity of graphene fiber microelectrodes. In our study, we use microfluidic spinning for creating graphene microfibers with exceptional qualities and tunable microstructures. By applying shear force, microfluidic spinning has enabled control over the fiber-forming process, while hydrodynamic focusing enables the fabrication of considerably thinner fiber. Fast scan cyclic voltammetry (FSCV) technique will be employed for further characterization of graphene oxide fiber microelectrodes, which will be used to study the sub-second release of neurochemicals in the brain.

Fabrication of graphene oxide fiber microelectrode on chip for neurochemical detection

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