In the traditional lab setting, many organic chemistry students find themselves following step-by-step instructions provided by the instructor and/or lab manual. This method does not allow the student to fully understand the underlying concepts or learn problem-solving skills in the lab. Course-Based Undergraduate Research Experiences (CURE) labs allow students to think critically about the science behind what they are doing, and problem solve along the way. At Northern Kentucky University (NKU), a sophomore Chemistry Lab course using the CURE approach was implemented in Fall 2020 and continued in the next two springs. In the Undergraduate Research in Organic Chemistry Course (UROCC), students were the major driving force to conduct original research and make discoveries on novel tropinone derivatives as potential anticancer agents. Computer modeling was also utilized to simulate the crucial interactions between the synthesized compounds and aromatase, an important pharmaceutical agent for breast cancer. The enzyme inhibition assay were utilized to test the IC<sub>50</sub> values of these compounds against human aromatase (CYP19). Due to the extent of original research content and continuous troubleshooting required, teaching assistants are indispensable for the successful implementation of this course. Two teaching assistants were involved for each lab section of 12 students to assist with special organic chemistry lab techniques and instrument operation to ensure all students had timely access to the resources necessary for success.

Undergraduate research in organic chemistry course (UROCC): Role of teaching assistants

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ACS Spring 2023

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.