Oxidative decarboxylative coupling reactions are becoming powerful methods to access functionalized arenes from widely available and inexpensive benzoic acids, yet many of these reactions are underutilized due to limitations in the scope of carboxylic acid coupling partner, the need for stoichiometric silver salt oxidants, and the high reaction temperatures required. Our recent efforts have focused on understanding the mechanisms of these reactions and the origins of these limitations to enable the design of efficient and universal decarboxylative coupling reactions. This talk will describe our recent mechanistic studies of copper-based catalyst systems including the measurement of reaction kinetics and the synthesis and study of organometallic reaction intermediates, as well as the development of new catalytic reactions designed to overcome the common limitations.

Mechanistic insights into copper-catalyzed oxidative decarboxylative coupling reactions

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