We report a MoS2-based optoelectronics biosensor for sensitive protein detection in liquid-phase. The sensor consisted of chemical vapor deposition grown single layer MoS2 film bridging source and drain electrodes on transparent and flexible Kapton substrate encapsulated with an atomic layer deposited (ALD) aluminum oxide (Al2O3) which was functionalized with antibody against target protein, human immunoglobulin G (HIgG) in this study. A photonic excitation light-emitting-diode (LED) of a visible red light (λ = 650 nm), with photoenergy matching the band gap of single layer MoS2 was introduced in the system as the source of light irradiation to induce a photocurrent for protein sensing. The resulting optoelectronic sensor exhibited a high sensitivity of 0.115 per Log[ng/mL], which was 2.4-fold greater than the sensitivity without illumination of 0.047 per Log[ng/mL]. The theoretical limit of detection (LOD) was estimated to be 7.57 ng/mL and 85.9 ng/mL, respectively, for sensing with and without illumination. Based on our experimental results, MoS2-based optoelectronic biosensors features high sensitivity and instant detection feedback for HIgG, and good specificity by showing no significant signals to non-target proteins whether in simple matrix such as buffer and complex matrix such as urine. This study demonstrates that biofunctionalized MoS2-based flexible optoelectronic is a promising candidate for the detection of various biomolecules and biomarkers of interest with low cost to advance the early disease diagnostics.

Two-dimensional molybdenum disulfide-based flexible optoelectronic biosensor for sensitive and selective detection of human immunoglobulin G

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