H2S has shown great promise as a therapeutic gas for various medical applications such as stents and for gastrointestinal issues. Due to release rates for small molecules H2S donors being too fast and for some applications, polymeric H2S donors are a promising alternative. Utilizing polysaccharides for these polymeric H2S donors is promising due to their low toxicity, natural abundance, and water solubility. In this work, we use amylopectin as a polysaccharide backbone and connect a small molecule H2S donor via thiol-ene “click” photochemistry. We applied acid degradation to vary the molecular weights of amylopectin to tune H2S release rates. We utilized GlcoMIP’s user facilities to measure the molecular weights of our polymers.

Polysaccharide H2S donors: Amylopectin N-(thiocarboxyanhydride) polymers via thiol-ene “click” photochemistry

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