Along with glutathione, biological thiol cysteine (Cys) plays important roles in many biological processes such as cellular detoxification and metabolism in living organisms. Changes in intracellular Cys concentration have a profound effect on these biological processes. Given the critical importance of Cys homeostasis in biological systems, a strong interest has emerged in developing effective probes to detect and image Cys-rich proteins. In this presentation, the synthesis and evaluation of probes which we are working on and would be used to label Cys-rich proteins in biological systems, especially in some diseases, will be presented.

Synthesis and evaluation of rhodamine- and biotin- probes for detection of cysteine-containing proteins

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ACS Spring 2023

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