Nanoporous gold nanoparticles (np-AuNPs) have been emerging as a promising tool in the field of biomedical applications such as biosensing because of their unique chemical and physical properties such as good biocompatibility, ease of surface modification, high surface-to-volume ratio, high stability, good conductivity, effective catalytic behavior, and high density. Nanoporous gold nanoparticles possess higher biomolecule loading and sensing capabilities as compared to gold nanoparticles (AuNPs) because of their higher surface area to volume ratio, however, the synthesis of these np-AuNPs in colloidal form with tunable size remains a great challenge. Here, we propose a method of fabrication of np-AuNPs in colloidal form using a wet chemical method. The synthetic strategies involve the seedless synthesis of gold/silver (Au/Ag) alloy nanoparticles by co-reduction followed by dealloying. Au/Ag alloy nanoparticles synthesized by co-reduction of chloroauric acid and silver nitrate solution using ascorbic acid were treated with nitric acid to form the np-AuNPs. The np-AuNPs of different sizes ranging from 130 nm to 450 nm were formed by varying the molar ratio of gold to silver. Furthermore, these np-AuNPs were immobilized onto a surface of indium tin oxide (ITO) – coated glass surface to use it as an electrode in the future for biosensing. The fabrication of these np-AuNPs and their immobilization on the electrode surface were observed and characterized by using UV-vis spectroscopy and scanning electron microscopy (SEM).

Colloidal nanoporous gold nanoparticles synthesis

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