Second near-infrared window (NIR-II) fluorescence imaging, as a new non-invasive imaging technique, has attracted extensive attention due to its simple operation, high biocompatibility, and real-time feedback of physiological activities. Compared with visible light (400-700 nm) and first near-infrared window (NIR-I, 700-900 nm), fluorescence imaging exhibits significant advantages in the NIR-II (900-1700 nm) region with weaker tissue scattering, lower autofluorescence and phototoxicity. Therefore, the development of highperformance NIR-II fluorophores enable high-resolution imaging of deep tissues, showing great application potential in clinical surgical navigation. However, to meet the requirement of fluorescent surgical navigation, the development of high-performance NIR-II fluorophores still face severe challenges for their clinic translation: Firstly, current NIR-II fluorescent dyes have single core, complex molecular structures, and difficult synthesis and modification. It is still difficult to regulate its photophysical and chemical properties. Secondly, the strucutures of NIRII fluorophores mostly contains stronger aromaticity and large conjugated structures, thereby leading to their aggregation-caused quenching in circulating blood and difficult assembly with albumin. So far, near-infrared dyes with both strong absorption and emission in the NIR-II region have rarely been reported, epecially the lack of high affinity for albumin in blood. In addition, most of the existing NIR-II dyes are metabolized slowly due to their large conjugated structure and strong hydrophobicity, and are easily retained in important organs such as the liver and spleen, seriously hindering their application translation. Therefore, there is an urgent need to develop new high-performance NIR-II fluorophores, which will greatly facilitate the translation of near-infrared fluorescence imaging technology into clinical applications.

Exploring novel quinocyanine dyes as NIR-II benchmarks for <i>in vivo</i> imaging against FDA-approved clinical Indocyanine green

Where thousands of chemistry professionals meet to share ideas and advance scientific and technical knowledge. Spring 2023 abstracts, posters, and presentations will launch at the end of March.

ACS Spring 2023

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

Exploring novel quinocyanine dyes as NIR-II benchmarks for in vivo imaging against FDA-approved clinical Indocyanine green