Molecules that enable the controlled delivery of carbon monoxide (CO) in biological environments are of significant current interest for research and possible therapeutic applications. Low doses of CO can produce beneficial health effects, including vasodilation, anti-inflammatory, and anticancer effects. We are focusing on the development of 3-hydroxyflavone (3-Hfl) derivatives as visible light-induced CO delivery molecules. Within this family of compounds, extended 3-Hfl derivatives can be tracked in cells and localized to specific subcellular organelles for targeted CO delivery. This presentation will focus on how 3-Hfl derivatives are being advanced as CO delivery motifs, and will include new studies on using metal flavonolato complexes for CO delivery in cellular environments.

Carbon monoxide (CO) delivery using flavonols and metal flavonolato complexes

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