Converting CO2 to value-added products represents a key opportunity to incentivize CO2 capture and mitigate global warming. The soil bacterium Cupriavidus necator can grow on CO2 as its sole carbon source when provided with H2 as an energy source and O2 for aerobic respiration, both of which can be generated by electrolysis of water using renewable electricity. Alternatively, CO2 can be electrocatalytically reduced to generate formate, which C. necator can use as its sole source of carbon and energy. C. necator is also amenable to genetic manipulation and can be engineered to convert CO2, directly or via formate, to numerous products across a range of applications. Here we will describe our progress toward developing C. necator as a microbial host to enable hybrid electrocatalytic/biocatalytic systems for production of fuels and chemicals from renewable electricity and CO2.

Improving Cupriavidus necator as host for conversion of CO2 to fuels and chemicals

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