Developing new greener synthetic methods for strategically significant organic transformations is of fundamental importance in organic chemistry towards sustainable scientific and industrial advancement. The application of visible light photoredox catalysis has revolutionized the field of organic synthesis by providing easier, cleaner and greener alternatives to numerous strategically important conventional reactions. However, most of the early visible-light photocatalytic approaches were heavily dependent on expensive heavy metal-ligand complex based catalytic systems. The quest to achieve an inexpensive, eco-friendly, metal-free alternative led to the development of organo-photocatalysts based visible light catalytic transformations. To that end, we have developed a number of new key organic transformations through visible light catalytic methods using an efficient acridinium based catalyst recently developed by us. Quinolin-2(1H)-ones are one of the important classes of compounds due to their prevalence in natural products and in pharmacologically useful compounds. We developed a reagent-free visible-light catalytic method for the room-temperature synthesis of variedly substituted Quinolin-2(1H)-ones. Single step synthesis of aryl alcohols, ethers, and esters under mild reaction condition provides a new route for the functionalization of benzene. We have developed a DDQ/TBN catalyzed visible-light methodology for the synthesis of aryl alcohols, ethers, and esters. Benzyl groups provide an easily achievable and very stable protection to hydroxyl groups of alcohols and acids via the formation of benzyl ethers and esters; however, their existing harsh deprotection techniques limit their widespread use in total synthesis. We have developed an efficient mild metal-free room-temperature method for highly selective debenzylation of benzyl ethers and esters using an organo-photocatalyst.

Efficient visible light-catalytic organic transformations using organo-photocatalysts

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