The Fe(II)- and 2-oxo-glutarate-dependent (Fe/2OG) enzymes are a superfamily of enzymes that catalyze a wide variety of biologically important and chemically diverse transformations. The Penn State bioinorganic group has studied these enzymes for two decades and elucidated various aspects of their reaction mechanisms. These findings and the unique collaborative infrastructure of the Penn State bioinorganic group provided the environment for Dr. Rachelle Copeland's groundbreaking thesis work on the so-called ethylene-forming enzyme (EFE), for which she was awarded with the 2023 Nobel Laureate Signature Award, and will be presented in this lecture.

Studies of the Fe/2OG enzymes at Penn State

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