The ideal global residue package is characterized by a harmonized Good Agricultural Practice (GAP) in different geographies, number of trials that meets national and global requirements, robust representative data of different climates zones resulting in globally harmonized MRLs. This concept brings benefits for the grower, for the regulators and for the registrants.  In different countries, the use of the same global critical GAP in residue studies can be challenging if we consider the efficacy and biology perspectives but can bring the advantage of one MRL for an specific active, facilitating international trade.  The present study case demonstrates that residues studies conducted in different geographies under the same critical GAP can derive the same MRL proposal. A total of 22 trials in cucurbits (muskmelon, melon, rockmelon and zucchini) were carried out in the United States (8 trials), Brazil (6 trials), Australia (8 trials) in 2020, 2021 and 2017, respectively, under the same critical GAP in a program designed for a Corteva<sup>TM</sup> active to be registered in its countries and to be used for a JMPR/Codex assessment. Even though different number of trials were placed to fulfil each local regulation, the residue levels found, that meet the proposed enforcement residue definition, provided the same MRL of 0.3 mg/kg (OECD MRL calculator) for each country. As consequence, globally harmonized MRL values eliminate trade barriers when complying with the GAP, which benefits the whole food chain.

Global GAP and harmonized MRL facilitating international trade study case

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