Inflammatory bowel disease (IBD) is a chronic, nonspecific disease that is refractory and therefore affects the normal life of patients to a great extent. Inspired by the antioxidant activity of natural enzymes in organisms, the therapeutic strategies of nanomaterials with enzyme-like activity (nanozymes) for inflammatory diseases have come into view. However, safe, effective and convenient administration of nanomaterials for IBD is one of the biggest difficulties in the field of nanomaterial therapy. To tackle this challenge, a system which couples multi-enzyme mimicking CeO2 nanoparticles with clinically approved montmorillonite (MMT) for IBD therapy is reported.We loaded cerium oxide on a montmorillonite surface to obtain CeO2@MMT nanozyme and verified that it has an excellent curative effect and universality in the treatment of IBD through in vitro and in vivo experiments. CeO2@MMT showed good superoxide dismutase- and catalase-like activity in vitro. Its electronegativity enables it to target the positively charged intestinal inflammatory site and exert an anti-inflammatory effect at the focus. Thus, it showed obvious curative effects and excellent biosafety in the treatment of Crohn's disease in mice, which broadened the spectrum of the application of nanozymes.

CeO2@montmorillonite nanozyme for Crohn’s disease therapy

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