<br/>Ideating and implementing undergraduate learning opportunities that simultaneously advanceresearch progress is challenging. Course-based Undergraduate Research Experiences(CUREs) that are nationally networked address this challenge by providing theinfrastructure forfaculty to plug into and easily integrate research into their classes.Design2Data (D2D) is agrowing nationally-networked CURE that involves students in investigating structure-functionrelationships in enzymes and collecting relevant data for the computational protein modelingand design stakeholder community. One of the tasks in this network is to identify enzymes thatare amenable to the already established D2D workflow. A good enzyme target must: have anavailable structure, expresswell inEscherichia coli(E. coli), utilize a colorimetric assay, and berelated to human health. One target here is tyrosinase.Tyrosinase iscopper-containingmetalloenzyme that catalyzes the oxidation of monophenols to ortho-diphenols and ortho-quinones. Tyrosinase plays a major role in the first step of the melanogenesis process. Workingwith tyrosinase can be a difficult task because the commercially available product can be impureand have low activity,makingtyrosinase a great candidate for recombinant studies.TyrosinasefromVerrucomicrobium spinosumcan be readily expressedinE. coli. This expressionsystemmakestyrosinase a good model enzyme for the D2D project

Utilizing tyrosinase as a model enzyme to explore structure-function relationships within a research collaboration network

Where thousands of chemistry professionals meet to share ideas and advance scientific and technical knowledge. Spring 2023 abstracts, posters, and presentations will launch at the end of March.

ACS Spring 2023

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.