Oxadiazoles are a class of organic compounds that are known to possess antibiotic properties. Previously, a novel 1,2,4 oxadiazole was synthesized. This compound was substituted with a 4-methoxybenzene and guanidine group, which contributes to making this compound an antibiotic candidate. Previous studies have shown that oxadiazole compounds have antibacterial properties toward gram-positive and gram-negative bacteria, but these results were only qualitative. Thus, this study focused on determining the minimum inhibitory concentration (MIC) of the compound. The antibacterial properties of the novel oxadiazole were tested on Enterococcus faecalis, a gram-positive bacterium, and Escherichia coli, a gram-negative bacterium. The MIC for both E. coli and E. faecalis are between 1 mM and 5 mM. Positive control assays were also done to observe the growth (or lack thereof) of each bacterium under the influence of ampicillin and chloramphenicol. There is evidence that the novel 1,2,4 oxadiazole possesses antibacterial properties against both E. coli and E. faecalis.

Antibacterial properties of a novel 1,2,4 oxadiazole

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