Organic multi-component crystalline materials have attracted attention in a wide range of high-technology applications. In this study, the interest is in examining cocrystallization as a means to alter the properties of solid-state fluorescent materials.<br/>Piroxicam (PRM) and meloxicam (MEL) are two nonsteroidal anti-inflammatory drugs, belonging to the Biopharmaceutics Classification System (BCS) Class II drugs. In this study, six novel pharmaceutical salts of PRM and MEL with three basic organic counterions, i.e., 4-aminopyridine (4-AP), 4-dimethylaminopyridine (4-DMP) and piperazine (PPZ) were prepared by both slow evaporation and slurrying. These salts were fully characterized by single crystal and powder X-ray diffraction, thermal analysis, and Fourier transform infrared spectroscopy. From the solubility experiments, all six salts, especially MEL-4DMP and MEL-4AP, showed a significantly improved apparent solubility and dissolution rate in sodium phosphate solution compared with the pure APIs.<br/>Furthermore, the PRM salts also exhibited solid-state luminescent properties. Hirshfeld surface analysis and HOMO-LUMO analysis supported the luminescent studies and the mechanism for the observed luminescence was discussed.

Pharmaceutical salts of piroxicam and meloxicam with organic counterions

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