<br/>Heteroaryl compounds function as inhibitors for certain enzymes, making it an important study in breast cancer research. The goal of this research focused on creating α-heteroaryl compounds via palladium-catalyzed direct heteroarylation of ketone under microwave irradiation. We used tropinone (I80) and 4-fluoroiodobenze (G61), an aromatic ring, to form heteroarylated tropinone, 2-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octan-3-one (I80-G61). The crude product was purified by Medium Pressure Liquid Chromatography (MPLC), followed by rotatory evaporation, and/or recrystallization using Craig tube. Nuclear Magnetic Resonance (NMR) was used to confirm that our synthesized product had the correct structure. Through this research we were able to further our knowledge on the conditions needed to synthesize our desired product, as well as learn about the role aromatase inhibitors have on treating breast cancer.

Undergraduate research in organic chemistry course (UROCC): Synthesis of new heteroaryl compounds for future treatment of breast cancer

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