Platinum compounds such as cisplatin and oxaliplatin are the most prevalent metal ion complexes in clinical use. The simplicity of these square-planar Pt(II) compounds makes them attractive targets for structure-function analysis, but such studies are confounded by the complexity of cellular targets. We and others have shown extensive interactions of Pt(II) compounds with cellular RNAs, demonstrating potential for influence outside of the canonical DNA damage response.  One remarkable example is the ability of oxaliplatin-like Pt(II) compounds containing 1,2-diaminocyclohexane ligands to specifically induce the nucleolar stress response. The nucleolus is the manufacturing district for ribosomes and a hub of cell signaling. Structure-function and mechanistic studies indicate that the influence of Pt(II) compounds in the nucleolus exhibits a surprising sensitivity to Pt(II) ligand size and other properties, suggesting that a relatively specific interaction is disrupted by platinum compounds that cause nucleolar stress. Current efforts are focused on determining the molecular mechanism of action of these small molecule platinum compounds that specifically induce nucleolar stress.

Metallobiochemistry and RNA: The platinum expansion

Where thousands of chemistry professionals meet to share ideas and advance scientific and technical knowledge. Spring 2023 abstracts, posters, and presentations will launch at the end of March.

ACS Spring 2023

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.