As a novel and efficient catalytic strategy, the metallaphotoredox has resulted in a renaissance in radical chemistry, specifically for the synthesis of chiral compound. Among them, the asymmetric catalysis of transition metals such as nickel, copper and palladium is more common, and other metals are relatively less studied. Not only that, these reactions tend to construct a central chirality at special reaction sites, such as benzyl and acrylic positions. It is of great scientific significance to develop novel photometal synergistic catalysis strategies and expand the types of visible light asymmetric catalysis. Cobalt, as a typical 3d metal, has attracted extensive attention in synthetic chemistry as a result of its wide source, good biocompatibility and unique chemical properties. Recently, we have developed a light/cobalt synergistic asymmetric catalytic model, realizing the visible light driven asymmetric reduction Grignard type addition reaction and asymmetric reduction Heck type coupling reaction by using the nucleophilic property of aryl cobalt species. Moreover, we also reported the first visible light driven cobalt catalyzed asymmetric radical coupling reaction. The synthesis of axial chiral heteroaryl compounds was achieved using a dynamic kinetic asymmetric conversion strategy. These methods have been successfully used for the asymmetric catalytic synthesis of chiral drugs with novel chiral AIE materials.

Visible light induced asymmetric cobalt catalytic reaction

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