The indole scaffold has served to provide a wide range of bioactive compounds with diverse activity. Our research group has previously reported the synthesis of a library of indolyl sulfonamide compounds to test for cytotoxicity. In addition, our lab has expanded our focus towards producing indolyl sulfonamides with various substitutions around the indole scaffold. In this investigation, we aim to synthesize analogs of the bioactive compounds to test for the importance of the sulfonamide unit in a structure activity relationship study. Our progress toward synthesizing a library of bioactive amide, ester, and sulfonate ester compounds on the indole scaffold will be presented.

Synthesis of a series of indolyl sulfonamide analogs to test for bioactivity in a structure activity relationship investigation

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