Fetal exposure to nicotine is known to impair regular breathing and heart rate after birth and is a risk factor for Sudden Infant Death Syndrome. In an effort to further investigate this relationship, this work aims to develop a reliable single-step extraction method paired with highly sensitive gas chromatography-mass spectrometry to detect and quantify low concentrations of nicotine, and its metabolite cotinine, in fetal murine plasma samples. The current chromatography run time per sample is ~5 min. To validate the method, limit of detection, linearity, accuracy, and precision are assessed.

Method development for GC/MS analysis of nicotine and its metabolites in plasma

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