Antibiotic resistance in Gram-negative bacteria is exacerbated due to decreased antibiotic development and accumulation issues. Prior research has shown that natural products and their derivatives account for 73% of approved antibacterial agents between 1981 and 2014 due to their unique structural motifs. When under a competitive environment with minimal media conditions, non-pathogenic rhizosphere soil bacteria possess the ability produce novel natural products in co-culture. It has also been demonstrated that antibiotic accumulation in Gram-negative bacteria is increased with the addition of guanidinylated functional groups. Herein, a two-fold approach to combating antibiotic resistance using natural product isolation and adjuvant-antibiotic hybrids will be discussed.

Two-tiered approach to combating antibiotic resistance

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ACS Spring 2023

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