The use of 4,4′-Dimethoxytrityl chloride (DMT-Cl) for hydroxyl group protection has a variety of applications. The DMT-protected functional group is widely used in solid-phase synthesis that includes the automatic synthesis of DNA, RNA, and peptides. DMT-protected solid support and nucleoside have been used during the coupling step in DNA oligonucleotide synthesis. Other applications that use DMT derivatives of amino acids can be used for peptide synthesis. Glycols and diols were tritylated under controlled and mild conditions. In this process complete consumption of trityl chloride was monitored by TLC then the reaction mixture was extracted to remove excess glycols, diols, and pyridinium salt. The majority of ditritylated bi-product and remaining pyridine were removed by precipitation. The tritylated product has a higher yield. Products were analyzed with TLC and ESI. The product does not require any expensive chromatographic separation.

Chromatography-free synthesis of mono DMT derivative of glycols and diols

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