Using commercially available Ellman’s auxiliary (<i>R, S, </i>and racemic 2-methyl-propanesulfinamide) we have developed a robust and scalable syntheses to precursors of chiral alkynyl functionalized beta amino acids. Beta-amino acids have been shown to possess enhanced stability to proteolysis, biological activity, as beta peptides, and as valuable moieties in drug design. An example of a drug utilizing a beta amino acid is <i>Sitagliptin</i> for therapeutic treatment of type 2 diabetes mellitus.

Pathways to precursors of chiral beta amino acids

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