Antibiotic resistance is becoming an increasing threat to our livelihood, and it is estimated that by 2050, there will be 10 million infections and over 35,000 deaths per year due to antibiotic-resistant bacteria. Previous research has shown that addition of guanidinium functionality to novel antibiotics effective against Gram-positive bacteria increase their effectiveness against Gram-negative bacteria. For this research, we synthesized a phenyl-guanidine base adjuvant and explored linking conditions to synthesize antibiotic-adjuvant hybrids. The adjuvant was successfully linked to ampicillin, sulfadiazine, and trimethoprim in separate trials using the same procedure, however yields were low. The adjuvants were tested in a cell-death assay against novel bacteria. Future work will be focused on increasing yield and purity of the antibiotic-adjuvant hybrids and testing them against pathogenic bacteria.

Synthesis and evaluation of guanidinium-based antibiotic adjuvant hybrids and their antibiotic properties

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