We have long been concerned with developing strategies and materials for the delivery of bioactive small molecules such as NO and CO to physiological targets. Although delivering these moieties to such sites has potential therapeutic applications, precise spatial-temporal control is essential. Photo-uncaging, in principle, allows one to define the location, timing and dosage of delivery and may serve both as an investigative tool and as a strategy for treating specific disease states. However, a key challenge in such photochemical delivery is the poor transmission of UV and Visible light through tissue.  Our recent studies to address this issue will be the subject of this presentation.

New strategies for uncaging small molecule bioregulators at physiological sites

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ACS Spring 2023

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