Polyhydroxylated indolizidines, a class of iminosugars (sugars mimics where the oxygen in the ring is replaced by a nitrogen), can play a key role in the modulation of the processing of carbohydrates as they are glycosidase inhibitors. As a result of this activity, polyhydroxylated indolizidines have great medicinal potential in the treatment of diseases such as AIDS, cancer, and diabetes.1 This research focused on synthesizing two stereoisomers of a tetrahydroxylated indolizidine 1 and 2 starting from D-galactose. The precursor epoxides 11 and 12 were tentatively formed and purified, and further analysis of them is needed to confirm.

Synthesis of polyhydroxylated indolizidines starting from D-glucopyranoside

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